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Product details

名称

(-)-TK216

英文名称

(-)-TK216

货号

T647888-5mg

包装规格

5mg

浓度

≥99%

储存温度

-20°C储存

运输条件

超低温冰袋运输

产品介绍

(-)-TK216 is an enantiomer of TK216 . TK216 is an orally active and potent E26 transformation specific (ETS) inhibitor. (-)-TK216 has anti-cancer activity. In Vitro (-)-TK216 (compound 14; for 3 days) has an IC 50 In Vivo (-)-TK216 (compound 14; 5 mg/kg for iv or 25 mg/kg for po) has T 1/2 s of 0.8 hours and 3.1 hours, and AUCs of 4131 h•(ng/mL) and 13152 h•(ng/mL) for iv and po, respectively, in BALB/c mice or Sprague Dawley rats. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid

生化机理

(-)-TK216 是 TK216 ( HY-122903 ) 的对映体。TK216 是一种具有口服活性的强效 E26 转化特异性（ETS）抑制剂。(-)-TK216 具有抗癌活性。

CAS号

1903783-78-7

分子式

C19H15Cl2NO3

分子量

376.23 g/mol

PubChem编号

121268274

IIUPAC Name

4,7-dichloro-3-[2-(4-cyclopropylphenyl)-2-oxoethyl]-3-hydroxy-1H-indol-2-one

INCHI

1S/C19H15Cl2NO3/c20-13-7-8-14(21)17-16(13)19(25,18(24)22-17)9-15(23)12-5-3-11(4-6-12)10-1-2-10/h3-8,10,25H,1-2,9H2,(H,22,24)

InChi Key

ZWHNLSHDLKIXOG-UHFFFAOYSA-N

Smiles

C1CC1C2=CC=C(C=C2)C(=O)CC3(C4=C(C=CC(=C4NC3=O)Cl)Cl)O

PubChem CID

121268274

溶解性

DMSO : 100 mg/mL (265.79 mM; Need ultrasonic)

氢键供体数Hydrogen Bond Donor Count

氢键受体数Hydrogen Bond Acceptor Count

可旋转键计数Rotatable Bond Count

精确质量Exact Mass

375.043 Da

单同位素质量Monoisotopic Mass

375.043 Da

拓扑极表面积Topological Polar Surface Area

66.400 Å²

重原子数Heavy Atom Count

形式电荷Formal Charge

复杂度Complexity

559.000

同位素原子数Isotope Atom Count

共价键合单元计数Covalently-Bonded Unit Count

XLogP3

4.100

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

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