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名称

Taprenepag isopropyl, 类前列腺素 EP2 受体激动剂

分子类型

小分子

别名

塔普尼帕异丙酯

英文别名

Taprenepag isopropyl [USAN] | 4-O- beta -D-Mannopyranosyl-D-glucopyranoside | isopropyl [3-({[4-(1H-pyrazol-1-yl)benzyl](pyridin-3-yl-sulfonyl)amino}methyl)phenoxy]acetate | isopropyl [3-({[4-(1H-pyrazol-1-yl)benzyl](pyridin-3-ylsulfonyl)-amino}methyl)phe

英文名称

Taprenepag isopropyl

货号

T648100-5mg

包装规格

5mg

浓度

≥98%

储存温度

-20°C储存

运输条件

超低温冰袋运输

产品介绍

Taprenepag isopropyl is a highly selective EP 2 receptor agonist. In Vivo Taprenepag isopropyl is a highly selective EP 2 receptor agonist. Intraocular pressure (IOP) in the left, vehicle-dosed eye typically remains within the normal range. In the right (Taprenepag isopropyl-dosed) eye, IOP is reduced in all dose groups. In the high-dose group, IOP is reduced to the extent that it cannot be measured ( Form:Solid IC50& Target:EP2

生化机理

Taprenepag isopropyl 是一种高选择性 EP 2 受体激动剂。

CAS号

1005549-94-9

分子式

C27H28N4O5S

分子量

520.6 g/mol

PubChem编号

23729077

Isomeric SMILES

CC(C)OC(=O)COC1=CC=CC(=C1)CN(CC2=CC=C(C=C2)N3C=CC=N3)S(=O)(=O)C4=CN=CC=C4

IIUPAC Name

propan-2-yl 2-[3-[[(4-pyrazol-1-ylphenyl)methyl-pyridin-3-ylsulfonylamino]methyl]phenoxy]acetate

INCHI

1S/C27H28N4O5S/c1-21(2)36-27(32)20-35-25-7-3-6-23(16-25)19-30(37(33,34)26-8-4-13-28-17-26)18-22-9-11-24(12-10-22)31-15-5-14-29-31/h3-17,21H,18-20H2,1-2H3

InChi Key

NVPXUFQLKWKBHK-UHFFFAOYSA-N

Smiles

CC(C)OC(=O)COC1=CC=CC(=C1)CN(CC2=CC=C(C=C2)N3C=CC=N3)S(=O)(=O)C4=CN=CC=C4

PubChem CID

23729077

溶解性

DMSO : 200 mg/mL (384.17 mM; Need ultrasonic)

氢键供体数Hydrogen Bond Donor Count

氢键受体数Hydrogen Bond Acceptor Count

可旋转键计数Rotatable Bond Count

精确质量Exact Mass

520.178 Da

单同位素质量Monoisotopic Mass

520.178 Da

拓扑极表面积Topological Polar Surface Area

112.000 Å²

重原子数Heavy Atom Count

形式电荷Formal Charge

复杂度Complexity

812

同位素原子数Isotope Atom Count

共价键合单元计数Covalently-Bonded Unit Count

XLogP3

3.6

作用类型

激动剂

作用机制

类前列腺素 EP2 受体激动剂

RIDADR

NONHforallmodesoftransport

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

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