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Product introduction

Tyk2-IN-7 is a TYK2 JH2 inhibitor, binds to TYK2 JH2 domain with IC50 and Ki.app of 0.00053 μM and 0.00007 μM, respectively. Tyk2-IN-7 provides a highly selective alternative to conventional TYK2 orthosteric inhibitors, inhibits TYK2/JAK1/JAK2 kinase domain. Tyk2-IN-7 provides robust inhibition in a mouse IL-12-induced IFNγ pharmacodynamic model as well as efficacy in an IL-23 and IL-12-dependent mouse colitis model. Form:Solid IC50& Target:Tyk2 JH2 0.00053 μM (IC 50 ) Tyk2 JH2 0.00007 μM (Ki app)

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Chinese name

Tyk2-IN-7

English name

Tyk2-IN-7

Chinese alias

English alias

CAS number

1609391-90-3

molecular formula

C18H15D3N6O3S

molecular weight

401.46 g/mol

Exact mass

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