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Product details

名称

TG6-10-1

分子类型

小分子

英文名称

TG6-10-1

货号

T650306-5mg

包装规格

5mg

浓度

≥99%

储存温度

-20°C储存

运输条件

超低温冰袋运输

产品介绍

TG6-10-1 is an EP2 antagonist, shows low-nanomolar antagonist activity against only EP2, >300-fold selectivity over human EP3, EP4, and IP receptors, 100-fold selectivity over EP1 receptors In Vitro TG6-10-1 robustly blocks prostaglandin E2 (PGE2) (10 μM)-induced cAMP accumulation in a concentration-dependent manner in SH-SY5Y cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo TG6-10-1 (5 mg/kg; i.p.; 4-30 hours) improves survival, accelerates recovery of lost weight, and improves functional recovery following status epilepticus (SE) . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: C57BL/6 mice (pilocarpine-induced SE) Dosage: 5 mg/kg Administration: Intraperitoneal injection; 4, 21, 30 hours Result: A significant increase in survival and accelerating the recovery of lost weight in post-SE mice. Form:Solid IC50& Target:EP2

生化机理

TG6-10-1 是一种 EP2 拮抗剂，仅对 EP2 具有低纳摩尔的拮抗活性，对人类 EP3、EP4 和 IP 受体的选择性大于 300 倍，对 EP1 受体的选择性为 100 倍。

CAS号

1415716-58-3

分子式

C23H23F3N2O4

分子量

448.4 g/mol

PubChem编号

71499384

Isomeric SMILES

COC1=CC(=CC(=C1OC)OC)/C=C/C(=O)NCCN2C3=CC=CC=C3C=C2C(F)(F)F

IIUPAC Name

(E)-N-[2-[2-(trifluoromethyl)indol-1-yl]ethyl]-3-(3,4,5-trimethoxyphenyl)prop-2-enamide

INCHI

1S/C23H23F3N2O4/c1-30-18-12-15(13-19(31-2)22(18)32-3)8-9-21(29)27-10-11-28-17-7-5-4-6-16(17)14-20(28)23(24,25)26/h4-9,12-14H,10-11H2,1-3H3,(H,27,29)/b9-8+

InChi Key

WUYOECAJFJFUFC-CMDGGOBGSA-N

Smiles

COC1=CC(=CC(=C1OC)OC)C=CC(=O)NCCN2C3=CC=CC=C3C=C2C(F)(F)F

PubChem CID

71499384

MeSH Entry Terms

TG6-10-1

溶解性

DMSO : 100 mg/mL (223.00 mM; Need ultrasonic)

氢键供体数Hydrogen Bond Donor Count

氢键受体数Hydrogen Bond Acceptor Count

可旋转键计数Rotatable Bond Count

精确质量Exact Mass

448.161 Da

单同位素质量Monoisotopic Mass

448.161 Da

拓扑极表面积Topological Polar Surface Area

61.700 Å²

重原子数Heavy Atom Count

形式电荷Formal Charge

复杂度Complexity

631

同位素原子数Isotope Atom Count

共价键合单元计数Covalently-Bonded Unit Count

XLogP3

4.2

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

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