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Product details

名称

Taltirelin acetate

别名

醋酸他替林

英文名称

Taltirelin acetate

货号

T651136-5mg

包装规格

5mg

浓度

≥98%

储存温度

-20°C储存,干燥

运输条件

超低温冰袋运输

产品介绍

Taltirelin acetate (TA-0910 acetate) is a superagonist at thyrotropin-releasing hormone receptor (TRH-R) with an IC 50 of 910 nM and EC 50 of 36 nM for stimulating an increase in cytosolic Ca 2+ concentration (Ca 2+ release) Form:Solid IC50& Target:IC50: 910 nM (Thyrotropin-releasing hormone receptor)

生化机理

醋酸他替瑞林（TA-0910）是促甲状腺激素释放激素受体（TRH-R）的超拮抗剂，其 IC 50 为 910 nM，EC 50 为 36 nM，可刺激细胞膜 Ca 2+ 浓度增加（Ca 2+ 释放）。

CAS号

1549593-23-8

分子式

C19H27N7O7

分子量

465.46 g/mol

PubChem编号

86346477

Isomeric SMILES

CC(=O)O.CN1C(=O)C[C@H](NC1=O)C(=O)N[C@@H](CC2=CN=CN2)C(=O)N3CCC[C@H]3C(=O)N

IIUPAC Name

acetic acid;(4S)-N-[(2S)-1-[(2S)-2-carbamoylpyrrolidin-1-yl]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]-1-methyl-2,6-dioxo-1,3-diazinane-4-carboxamide

INCHI

1S/C17H23N7O5.C2H4O2/c1-23-13(25)6-10(22-17(23)29)15(27)21-11(5-9-7-19-8-20-9)16(28)24-4-2-3-12(24)14(18)26;1-2(3)4/h7-8,10-12H,2-6H2,1H3,(H2,18,26)(H,19,20)(H,21,27)(H,22,29);1H3,(H,3,4)/t10-,11-,12-;/m0./s1

InChi Key

AQWPSTSKDKFSRT-LFELFHSZSA-N

Smiles

CC(=O)O.CN1C(=O)CC(NC1=O)C(=O)NC(CC2=CN=CN2)C(=O)N3CCCC3C(=O)N

PubChem CID

86346477

溶解性

DMSO : 125 mg/mL (268.55 mM; Need ultrasonic)

氢键供体数Hydrogen Bond Donor Count

氢键受体数Hydrogen Bond Acceptor Count

可旋转键计数Rotatable Bond Count

精确质量Exact Mass

465.197 Da

单同位素质量Monoisotopic Mass

465.197 Da

拓扑极表面积Topological Polar Surface Area

208.000 Å²

重原子数Heavy Atom Count

形式电荷Formal Charge

复杂度Complexity

745

同位素原子数Isotope Atom Count

共价键合单元计数Covalently-Bonded Unit Count

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

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