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Product introduction

DCP-LA是选择性的PKC-ε（PKC-ε）激活剂。在采用反相高效液相色谱的原位| PKC分析中，DCP-LA以浓度（10 nM-100μM）依赖性的方式显着激活PC-12细胞中的PKC，在100 nM时效果最大。。与其他PKC同工酶相比，DCP-LA激活PKC-ε的效力提高了7倍。 DCP-LA (FR236924), a linoleic acid derivative, selectively and directly activates PKCε. DCP-LA activates Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) and inhibits protein phosphatase-1 (PP-1) to stimulate AMPA receptor exocytosis. DCP-LA inhibits activation of caspase-3/-9 and protects neurons at least in part from oxidative stress-induced apoptosis.

Specs ⸢ View details ⸥

Chinese name

DCP-LA

English name

DCP-LA

Chinese alias

English alias

FR236924

CAS number

28399-31-7

molecular formula

C20H36O2

molecular weight

308.50 g/mol

Exact mass

≥95%

PSA

37.300 Å²

Logp

7.7

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