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Product details

名称

TP-020

分子类型

未知

英文名称

TP-020

货号

T655010-1ml

包装规格

1ml

浓度

10mM in DMSO

储存温度

-80℃储存

运输条件

超低温冰袋运输

产品介绍

TP-020 (MGAT2-IN-1) is an orally active inhibitor of monoacylglycerol acyltransferase (MGAT2) with IC 50 of 7.8 and 2.4 nM for human and mouse MGAT2 , respectively. In Vivo TP-020 (3, 10 mg/kg, p.o.) dose-dependently suppresses plasma TG elevation, and plasma CM/TG AUC in mice. TP-020 does not decrease MG absorption but inhibits MGAT2-dependent TG/DG resynthesis. In the lipid utilization analysis, TP-020 significantly increases free fatty acid (FFA) and acylcarnitine levels. TP-020 (30 mg/kg) also significantly reduces food intake dose dependently, suppresses BW gains. TP-020 shows anti-diabetic effects in mice . MCE has not independently confirmed the accuracy of these methods. They are for reference only. IC50& Target:IC50: 7.8 nM (Human MGAT2), 2.4 nM (Mouse MGAT2)

生化机理

TP-020（MGAT2-IN-1）是一种具有口服活性的单酰基甘油酰基转移酶（MGAT2）抑制剂，对人类和小鼠 MGAT2 的 IC50 分别为 7.8 和 2.4 nM。

CAS号

1800025-30-2(DMSO)

分子式

C27H21ClF5N7O3S

分子量

654.01 g/mol

Smiles

CN1C(=CC(=N1)C(F)(F)F)C2=CN=C(N=C2)N3CCC4=C3C(=CC(=C4)S(=O)(=O)NC5=C(C=C(C=C5F)Cl)F)N6CCCC6=O

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

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