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Product details

名称

TAK1/MAP4K2 inhibitor 1

别名

TAK1/MAP4K2 抑制剂 1

英文名称

TAK1/MAP4K2 inhibitor 1

货号

T655332-1ml

包装规格

1ml

浓度

10mM in DMSO

储存温度

-80℃储存

运输条件

超低温冰袋运输

产品介绍

TAK1/MAP4K2 inhibitor 1 is a potent dual TGFβ-activated kinase 1 ( TAK1 ) and mitogen-activated protein kinase kinase kinase kinase 2 ( MAP4K2 ) inhibitor, with IC 50 s of 41.1 nM and 18.2 nM, respectively. In Vivo TAK1/MAP4K2 inhibitor 1 has moderate terminal elimination half-life (t 1/2 =2.94 h for mice (1 mg/kg, iv)) . MCE has not independently confirmed the accuracy of these methods. They are for reference only. IC50& Target:TAK1 41.1 nM (IC 50 ) MAP4K2 18.2 nM (IC 50 )

生化机理

TAK1/MAP4K2 抑制剂 1 是一种强效的 TGFβ 激活激酶 1（TAK1）和丝裂原活化蛋白激酶激酶 2（MAP4K2）双重抑制剂，其 IC 50 s 分别为 41.1 nM 和 18.2 nM。

CAS号

1315330-11-0(DMSO)

分子式

C29H31F3N6O2

分子量

552.59 g/mol

Smiles

CCN1CCN(CC1)CC2=C(C=C(C=C2)NC(=O)C3=CC(=C(C=C3)C)OC4=NC=NC5=C4C=C(N5)C)C(F)(F)F

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

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