TMX-4100 is a selective phosphodiesterase 6D ( PDE6D ) degrader. TMX-4100 shows a high degradation preference for PDE6D with the DC 50 values less than 200 nM in MOLT4, Jurkat, and MM.1S cells. TMX-4100 can be used for the research of multiple myeloma In Vitro TMX-4100 (compound 3; 1 μM; 4 h) shows a high degradation preference for PDE6D in MOLT4 cells. TMX-4100 has better proteome-wide degradation selectivity in MOLT4 cells, compare to PDE6D degrader FPFT-2216. TMX-4100 does not impede the growth of KRAS-dependent cell lines (MIA PaCa-2, NCI-H358, AGS, PA-TU-8988T cells). MCE has not independently confirmed the accuracy of these methods. They are for reference only. Western Blot AnalysisCell Line: MOLT4 cells Concentration: 1 μM Incubation Time: 4 hours Result: Showed a high degradation preference for PDE6D. Western Blot AnalysisCell Line: MOLT4, Jurkat, and MM.1S cells Concentration: 0 nM, 40 nM, 200 nM, 1 μM; Incubation Time: 4 hours Result: Showed a high degradation preference for PDE6D with the DC 50 value less than 200 nM. Form:Solid IC50& Target:PDE6 PDE6D