Teriflunomide impurity 3 (4-Amino-N-(4-trifluoromethylphenyl)benzamide) is a selective COX-1 inhibitor with an IC 50 of 30 µM. Teriflunomide impurity 3 is less active against COX-2 (IC 50 >100 µM) In Vitro Teriflunomide impurity 3 (4-Amino-N-(4-trifluoromethylphenyl)benzamide; compound 11q) is an amide-bond-reversed compound bearing trifluoromethyl and amino substituents showed potent COX-1-selective inhibitory activity. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:COX-1 30 μM (IC 50 )