- Treatment： 通常需要透析以缓解尿毒症综合征的症状，直到肾脏功能恢复正常为止。
- exposure pathway： 内源性、摄入、皮肤接触（接触）
- Toxicity summary： 尿毒症毒素如α-酮 -δ-胍氨酸乙酸通过有机离子转运体（尤其是 OAT3）主动运输到肾脏。尿毒症毒素水平升高可刺激活性氧的产生。这似乎是由尿毒症毒素直接结合或抑制酶 NADPH 氧化酶介导的（特别是 NOX4，在肾脏和心脏中丰富）(A7868)。活性氧可以诱导几种不同的 DNA 甲基转移酶 (DNMTs)，它们参与已知为 KLOTHO 蛋白的沉默。KLOTHO 已被确定为具有抗衰老、矿物质代谢和维生素 D 代谢的重要作用。多项研究表明，急性或慢性肾脏病期间 KLOTHO mRNA 和蛋白质水平降低...
- Health Effects： 慢性暴露于尿毒症毒素可导致多种状况，包括肾损伤、慢性肾脏病和心血管疾病。
- Symptoms and Signs： 作为一种尿毒症毒素，该化合物可引起尿毒症综合征。尿毒症综合征可能影响身体的任何部分，并可能导致恶心、呕吐、食欲不振和体重减轻。它还可能导致精神状态改变，如困惑、意识降低、烦躁、精神病、癫痫发作和昏迷。异常出血，例如从轻微伤害中自发或大量出血也可能发生。心脏问题，如心律不齐、围绕心脏的囊膜发炎（心包炎）以及心脏压力增加可在尿毒症综合征患者中看到。由于肺部和胸壁之间的空间积液导致的呼吸困难也可能存在。
- Hazard categories and classifications： STOT SE 3 (100%)
- Carcinogen Classification： 对人类无致癌性指示（未列入 IARC）。
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5-(diaminomethylideneamino)-2-oxo-pentanoic acid 10mg
Yuanye 5-(diaminomethylideneamino)-2-oxo-pentanoic acid 10mg, CAS 3715-10-4, complete specifications; suitable for production, research, laboratory testing and inspection; digital one-stop procurement platform for scientific materials.
