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Product details

名称

TMC647055 Choline salt

别名

TMC647055 胆碱盐

英文名称

TMC647055 Choline salt

货号

T658919-5mg

包装规格

5mg

浓度

≥99%

储存温度

2-8°C储存,干燥

运输条件

冰袋运输

产品介绍

TMC647055 (Choline salt) is a potent nonnucleoside NS5B polymerase inhibitor of HCV replication . TMC647055 Choline salt has potent HCV combine activity with an IC 50 value of 82 nM. TMC647055 Choline salt can be used for the research of Hepatitis C virus Appearance:Solid IC50& Target:EC90: 0.3 μM (Huh7-Luc cell) . EC50: 82 nM (HCV) In Vitro:TMC647055 (Choline salt) has antiviral activity with an EC 90 value of 0.3 μM in Huh7-Luc cells. TMC647055 Choline salt has potent combine activity with an EC 50 value of 82 nM in cellular HCV assays. MCE has not independently confirmed the accu In Vivo:TMC647055 Choline salt (compound 18a) (2mg/kg, iv.; 1mg/kg, po.) shows an acceptable PK profile, characterized by high oral bioavailability and high systemic exposure after single oral dosing of 10mg/kg, combined with a moderate plasma clearanceand low Biological Activity:TMC647055 (Choline salt) is a potent nonnucleoside NS5B polymerase inhibitor of HCV replication . TMC647055 Choline salt has potent HCV combine activity with an IC 50 value of 82 nM. TMC647055 Choline salt can be used for the research of Hepatitis C virus

分子式

C37H53N5O8S

分子量

727.91 g/mol

Smiles

OCC[N+](C)(C)C.COC1=CC2=C(C=C1)C3=C(C4CCCCC4)C5=CC=C(C6=O)C=C5N3CC(C(N(C)CCOCCN(S(N6)(=O)=O)C)=O)=C2.[OH-]

溶解性

DMSO : 62.5 mg/mL (85.86 mM; ultrasonic and warming and heat to 60°C)

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

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「No related articles yet」

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