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名称

Tigecycline tetramesylate

别名

四甲磺酸替加环素

英文名称

Tigecycline tetramesylate

货号

T659191-50mg

包装规格

50mg

浓度

≥95%

储存温度

2-8°C储存,干燥

运输条件

冰袋运输

产品介绍

Tigecycline tetramesylate (GAR-936 tetramesylate) is a broad-spectrum glycylcycline antibiotic . The mean inhibitory concentration (MIC) of Tigecycline for E. coli (MG1655 strain) is approximately 125 ng/mL. MIC 50 and MIC 90 are 1 and 2 mg/L for Aci Appearance:Solid IC50& Target:Mean MIC: 125 ng/mL ( E. coli ) MIC50: 1 mg/mL ( A. baumannii ) MIC90: 2 mg/mL ( A. baumannii ) In Vitro:Tigecycline (0.63-30 µM, preincubated for 4 days, treated for 72 h) inhibits AML2 cells and HL-60 cells with IC 50 s of 4.72±0.54 and 3.06±0.85 μM (freshly prepared). Tigecycline inhibits AML2 cells and HL-60 cells with IC 50 s of 5.64±0.55 and 4.27±0.45 In Vivo:Tigecycline (50mg/kg; intraperitoneal injection; twice a day; for 11 days) reduces tumor volume and weight in NOD/SCID mice. The peak plasma concentration (C max ), the terminal half-life (t 1/2 ), area under the plasma concentration-time curve (AUC Biological Activity:Tigecycline tetramesylate (GAR-936 tetramesylate) is a broad-spectrum glycylcycline antibiotic . The mean inhibitory concentration (MIC) of Tigecycline for E. coli (MG1655 strain) is approximately 125 ng/mL. MIC 50 and MIC 90 are 1 and 2 mg/L for Aci

分子式

C33H55N5O20S4

分子量

970.07 g/mol

Smiles

O=S(C)(O)=O.O=S(C)(O)=O.O=S(C)(O)=O.O=C(C(C1=O)=C(O)[C@@H](N(C)C)[C@]2([H])C[C@]3([H])CC4=C(C(C3=C(O)[C@@]21O)=O)C(O)=C(NC(CNC(C)(C)C)=O)C=C4N(C)C)N.O=S(C)(O)=O

溶解性

DMSO : 100 mg/mL (103.09 mM; Need ultrasonic) H2O : 50 mg/mL (51.54 mM; Need ultrasonic)

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

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