TD52 dihydrochloride

TD52 二盐酸盐

TD52 dihydrochloride

T659333-5mg

5mg

≥99%

-20°C储存

超低温冰袋运输

TD52 dihydrochloride, an Erlotinib ( HY-50896 ) derivative, is an orally active, potent cancerous inhibitor of protein phosphatase 2A (CIP2A) inhibitor. TD52 dihydrochloride mediates the apoptotic effect in triple-negative breast cancer (TNBC) cells via r Appearance:Solid In Vitro:TD52 dihydrochloride (2-10 μM; 48 hours) shows anti-proliferative ability and induces differential apoptotic effects in these cell lines. TD52 dihydrochloride (5 μM; 48 hours) has minimal effects on p-EGFR or EGFR expression but downregulated CIP2A e In Vivo:TD52 dihydrochloride (10mg/kg/day; oral gavage; for 52 days) significantly inhibits MDA-MB-468 xenograft tumour size and tumour weight. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Biological Activity:TD52 dihydrochloride, an Erlotinib ( HY-50896 ) derivative, is an orally active, potent cancerous inhibitor of protein phosphatase 2A (CIP2A) inhibitor. TD52 dihydrochloride mediates the apoptotic effect in triple-negative breast cancer (TNBC) cells via r

C24H18Cl2N4

433.33 g/mol

C#CC1=CC(NC2=NC3=CC=CC=C3N=C2NC4=CC=CC(C#C)=C4)=CC=C1.[H]Cl.[H]Cl

DMSO : 25 mg/mL (57.69 mM; ultrasonic and warming and heat to 60°C)