呈强酸性，有毒，能与水及醇混和，对皮肤和粘膜有强腐蚀性，并能刺激眼和呼吸道。常温下不腐蚀玻璃，但其浓溶液不能长期贮存于玻璃瓶中。 制备稳定的重氮盐类，制造缩醛催化，在镁离子和钾离子存在下测定钠的试剂 有机合成的催化剂，还用于海棉钛及其合金的--溶解和印刷线路板工业。 Tetrafluoroboric acid is used as a catalyst for the protection and deprotection reactions of various carbohydrates. It participates in the synthesis of 4-sulfonic acid phenyl diazonium tetrafluoroborate, which was required for the preparation of sulfonated graphene (SG). Tetrafluoroboric acid solution may be used as a catalyst for the hydration of aromatic haloalkynes to α-halomethyl ketones in the absence of metal catalysts. It may also be used the epoxidized soybean oil (ESBO) ring opening step of fatty acids preparation.