- exposure pathway： 迅速吸收。食物可将吸收程度提高30%至85%。
- Toxicity summary： 曲格列酮是一种噻唑烷二酮类抗糖尿病药物，通过改善靶细胞对胰岛素的反应来降低血糖。它具有独特的作用机制，其活性依赖于胰岛素的存在。曲格列酮减少肝脏葡萄糖输出，增加骨骼肌中胰岛素依赖性葡萄糖处置。其作用机制被认为涉及与核受体(PPAR)结合，该受体调节一系列对胰岛素敏感的基因转录，这些基因对葡萄糖和脂质代谢的控制至关重要。曲格列酮既是PPARα又是PPARγ的配体，对PPARγ具有更高的亲和力。该药物还含有α-生育酚基团，可能赋予其类似维生素E的活性。研究表明曲格列酮具有抗炎作用，并与...
- Hepatotoxicity： 可能性评分: A (公认的明显肝损伤原因)。
- Carcinogen Classification： 对人类无致癌性迹象（未被IARC列出）。
- Drug Induced Liver Injury： 参考文献：DOI:10.1016/j.drudis.2019.09.022
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Troglitazone 10mM in DMSO 1ml
Troglitazone 10mM in DMSO 1ml Macklin 97322-87-7, complete specifications, for production, research, laboratory testing and inspection, digital one-stop procurement platform for scientific materials.
