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Product introduction

产品介绍： A cell-permeable indolinone compound that acts as a potent, ATP site-targeting PDGFR inhibitor (IC50 = 10 nM against PDGFRβ), while affecting Flk-1/KDR/ VEGFR2, FGFR1, and EGFR only at much higher concentrations (IC50 = 0.14, 2.29, and >100 µM, respectively). Reported to selectively inhibit PDGFβ- over EGF-stimulated proliferation in EGFR-expressing NIH 3T3 cultures (IC50 = 0.11 and 21.9 µM, respectively) and exhibit much weaker potency against the proliferation of HUVEC cells upon FGF or VEGF stimulation (IC50 = 10 µM).

Specs ⸢ View details ⸥

Chinese name

SU 16f,PDGFRβ抑制剂

English name

SU 16f

Chinese alias

5-[1,2-二氢-2-氧代-6-苯基-3H-吲哚-3-亚甲基)甲基] -2,4-二甲基-1H-吡咯-3-丙酸

English alias

(Z)-3-(2,4-Dimethyl-5-(2-oxo-1,2-dihydro-indol-3-ylidenemethyl-6-phenyl)-1H-pyrrol-3-yl)-propionic acid | VEGFR Tyrosine Kinase Inhibitor XXXI | VEGFR2 Kinase Inhibitor XXIX | (E)-3-(2,4-dimethyl-5-((2-oxo-6-phenylindolin-3-ylidene)methyl)-1H-pyrrol-3-yl)

CAS number

251356-45-3

molecular formula

C24H22N2O3

molecular weight

386.44 g/mol

Exact mass

≥98%(HPLC)

PSA

82.200 Å²

Logp

3.900

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Research chemical 98% 100mg

Name: Research chemical 98% 100mg
Brand: MedMol
SKU: T84202-100mg

Research chemical 98% 100mg, complete specifications; suitable for production, research, laboratory testing and inspection; digital one-stop procurement platform for scientific materials.

item number：T84202-100mg

Product model：100mg

level： 98% 100mg

Lead Time：30days

sold 689 Items

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Research chemical 98% 100mg

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