Tilivalline 是产酸克雷伯菌的一种代谢产物。已知Tilivalline 具有细胞毒性。Tilivalline 的代谢被证明与抗生素相关的出血性结肠炎有关。可以在曼尼希型分子内环化反应中，从叠氮基磷酸二苯酯，2-恶唑啉，L-脯氨酸衍生物5和吲哚高效地和立体选择性地合成替利伐林的衍生物。 Tilivalline is a metabolite of Klebsiella oxytoca. Tilivalline is known to be cytotoxic. The metabolization of Tilivalline is propven to be linked to antibiotic-associated Hemorrhagic Colitis. The derivatives of Tilivalline were able to be synthesized efficiently and stereoselectively from diphenyl phosphorazidate, the 2-oxazoline, L-proline derivatives 5, and Indole in a Mannich-type intramolecular cyclization reaction.