iFSP1 是 FSP1 (AIFM2) 的选择性有效抑制剂， iFSP1 可选择性地诱导过表达 FSP1 的 GPX4 敲除细胞发生铁死亡 (ferroptosis)。iFSP1 可增强多种人癌细胞系对铁死亡诱导剂的敏感度。 Information iFSP1 iFSP1 is a potent, selective and glutathione-independent inhibitor of ferroptosis suppressor protein 1 (FSP1/AIFM2) with EC50 of 103 nM. iFSP1 selectively induces ferroptosis in GPX4-knockout Pfa1 and HT1080 cells that overexpresses FSP1. Targets FSP1/AIFM2 (Cell-free assay) 103 nM(EC50) In vitro iFSP1 selectively induces ferroptosis in GPX4-knockout Pfa1 and HT1080 cells that overexpressed FSP1. FSP1 is expressed in most tumour cell lines, and iFSP1 treatment robustly sensitizes these cells to RSL3-induced ferroptosis. Cell Research(from reference) Cell lines：human cancer cell lines (NCl-H1437, U-373, MDA-MB-436, SW620, MDA-MB-435S, A549, etc.) Concentrations：0.01 μM - 10 μM, 3 μM Incubation Time：24 h