
- Health hazard: 急性/慢性危害:该化合物引起皮肤、眼睛和粘膜刺激。(NTP, 1992)
- Hazard summary: 紧急治疗:香豆素;摄入4克香豆素后,患者出现肌肉麻痹但无心血管效应;大鼠有肝毒性,但人类相对耐受;不作为抗凝血剂使用;作为食品香料使用时安全;[JECFA] 致癌物和刺激物;在大鼠致死剂量喂养研究中引起嗜睡;[RTECS] 皮肤、眼睛和粘膜刺激性物质;[CAMEO] 刺激性物质;[MSDSonline] 参见香豆素。
- reactive group: 酯类、硫酸酯、磷酸酯、硫代磷酸酯和硼酸酯
- Disposal method: SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.
- First aid measures: 摄入:不要催吐。如果受害者意识清醒且未抽搐,给予 1-2 杯水稀释化学品并立即呼叫医院或中毒控制中心。如医生建议,准备好将受害者转运至医院。如果受害者抽搐或不省人事,切勿经口喂食任何东西,确保受害者气道通畅并将受害者侧卧放置于头部低于身体的位置。不要催吐。立即将受害者送往医院。(NTP, 1992)
- Harmful effect: 职业性肝毒素 - 继发性肝毒素:环境中的毒性效应潜力基于人摄入中毒或动物实验的案例。
- Regulatory information: 新西兰 EPA 化学品状态清单:二氢香豆素:没有单独的批准,但可在适当的群体标准下使用。
- fire hazard: 该化学品可燃。(NTP, 1992)
- fire fighting: 涉及该材料的火灾可用干粉灭火器、二氧化碳或哈龙灭火器控制。(NTP, 1992)
- interaction: 以下药物...可能...降低...对香豆素或茚并二酮衍生物的反应:酒精(慢性酒精中毒),巴比妥类,卡马西平,皮质类固醇,促肾上腺皮质激素,乙氯维诺尔,格鲁替咪德,灰黄霉素,巯嘌呤,美沙酮,含雌激素的口服避孕药,利福平,螺内酯,维生素 K。/香豆素 & 茚并二酮衍生物/
- Special Reports: DHHS/NTP; 3,4-二氢香豆素在 F344/N 大鼠和 B6C3F1 小鼠中的毒理与致癌性研究(灌胃研究)技术报告系列第 423 号 (1993) NIH Publication No. 93-3154
- reactivity profile: 3,4-二氢香豆素是一种内酯(表现为酯类)。酯与酸反应会释放热量并生成醇和酸。强氧化性酸可能引起剧烈反应,该反应的放热足以点燃反应产物。酯与碱性溶液相互作用也会产生热量。将酯与碱金属和水合氢离子混合会产生易燃的氢气。该物质可在碱性或酸性条件下水解。(NTP, 1992)
- Other safety information: 化学评估:IMAP 评估 - 香豆素类:人类健康二级评估
- Air and water reaction: 该化学品在水中的溶液稳定性小于两小时。不溶于水。
- non-human toxicity value: LD50 豚鼠口服 1760 mg/kg
- Hazard categories and classifications: 皮肤致敏 - 类别1
- Non-human toxic extract: /致突变性/ 带有或不带 S9 的两种沙门氏菌基因突变测试结果为阴性。
- Non-fire leakage response: 储存注意事项:您应在环境温度下存储此材料。远离点火源。(NTP, 1992)
- Personal protective equipment (PPE): 推荐呼吸器:当称量并稀释纯测试化学品时,佩戴 NIOSH 批准的半面罩式呼吸器,配备有机蒸气/酸气滤毒盒(针对有机蒸气、氯化氢、酸性气体和二氧化硫专用)以及粉尘/雾滴过滤器。(NTP, 1992)
- Carcinogen Classification: 摘要:3,4-二氢香豆素导致雄性大鼠胃前庭溃疡、增生和炎症,甲状旁腺增生以及肾病的严重程度增加。
- Natural Pollution Sources: 报道发现于Melilotus officinalis(Phipson, Chem News, 32, 25, 1875),可通过水蒸馏从中提取。
- Populations at Special Risk: SRP:有出血性疾病或正在服用抗凝血药的人应免受暴露。
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Research chemical CAS 119-84-6 1ml
Yuanye Research chemical CAS 119-84-6 1ml, complete specifications; suitable for production, research, laboratory testing and inspection; digital one-stop procurement platform for scientific materials.




