Share to

Overview

Specs

Technical Documents

Articles

reviews

Consult

returns

Product introduction

Takinib belongs to the aminobenzimidazole class of inhibitors. Takinib (EDHS-206) 是一种有效且选择性的 TAK1 抑制剂 (IC50=9.5 nM)，比 IRAK4 (IC50=120 nM) 和 IRAK1 (IC50=390 nM) 作用强 1.5 log 倍。Takinib 是一种TAK1自磷酸化的抑制剂，在 ATP 结合口袋内非竞争性结合。在类风湿关节炎和转移性乳腺癌细胞模型中，Takinib 诱导 TNF-α 刺激的细胞凋亡 (apoptosis)。Takinib 也是恶性疟原虫蛋白激酶 9 (PfPK9) 的抑制剂 (KD(app) of 0.46 nM)。 Application Takinib has been used as an inhibitor of transforming 28 growth factor - β-activated kinase -1 (TAK-1) in human leukemia monocytic THP-1 cells. It may be used as a TAK1 inhibitor in Jurkat cells.

Specs ⸢ View details ⸥

Chinese name

Takinib,TAK1/MAP3K7激酶抑制剂, CDC 类激酶 2 抑制剂

English name

Takinib

Chinese alias

English alias

N17080 | SCHEMBL20063046 | F0918-1884 | A928060 | Tox21_300612 | Diethyl phthalate, 99% | NSC789624 | NSC-789624 | UNII-Z56NTB3YHJ | CCG-267729 | Z332866662 | 1-N-(1-propyl-1H-1,3-benzodiazol-2-yl)benzene-1,3-dicarboxamide | AKOS037515558 | GTPL9655 | MFC

CAS number

1111556-37-6

molecular formula

C18H18N4O2

molecular weight

322.37 g/mol

Exact mass

PSA

90.000 Å²

Logp

2.300

Technical Documents

「No technical documents」

「No upstream and downstream information yet」

Articles

「No related articles yet」

user reviews

Consultation

Warm reminder：

Because the manufacturer may temporarily adjust product specifications, prices, inventory, parameters and other information without notice, and there are differences in each user's consultation time and procurement needs, the platform reply content is only of reference value within a certain period. Sorry for the inconvenience caused to you, and thank you for your understanding and support! Please consult the online customer service for the latest details. Everything is subject to the real-time reply of the customer service.！

After Sales Services

Please check the quantity, appearance and product information in time when you receive the goods. In case of damage, wrong delivery, abnormal quality and other problems, please feel free to contact us.

Service Hotline:400-6226-992 ，We will handle it for you as soon as possible, thank you for your support and trust.！

Research chemical CAS 1111556-37-6 1ml

Name: Research chemical CAS 1111556-37-6 1ml
Brand: 源叶
SKU: T93078-1ml

Yuanye Research chemical CAS 1111556-37-6 1ml, complete specifications; suitable for production, research, laboratory testing and inspection; digital one-stop procurement platform for scientific materials.

item number：T93078-1ml

Product model：1ml

level： 1ml

Lead Time：30days

sold 54 Items

Ask Solution engineer

Qty

Research chemical CAS 1111556-37-6 1ml

Recommended for you