- exposure pathway： 外用
- Toxicity summary： 咪康唑与14-α脱甲基酶相互作用，这是一种将羊毛甾醇转化为麦角甾醇所需的细胞色素P-450酶。由于麦角甾醇是真菌细胞膜的必需成分，抑制其合成会导致细胞通透性增加，引起细胞内容物泄漏。咪康唑还可抑制内源性呼吸，与膜磷脂相互作用，抑制酵母菌向菌丝形态的转化，抑制嘌呤摄取，并损害甘油三酯和/或磷脂的生物合成。
- Regulatory information： 新西兰EPA化学品状态清单：咪康唑：没有单独批准，但可作为符合团体标准的产品成分使用。它不被批准作为化学品单独使用。
- Toxicity Data： LD50: 3800 mg/kg (口服, 小鼠) (A308) LD50: 3 gm/kg (口服, 大鼠) (A308)
- Symptoms and Signs： 摄入一管霜剂中所含成分的量不太可能导致过量服用和毒性反应。
- Other safety information： 化学品评估：IMAP评估 - 1H-咪唑，1-[2-(2,4-二氯苯基)-2-[(2,4-二氯苯基)甲氧基]乙基]-：人类健康一级评估
- Hazard categories and classifications： 水生慢性4级（39.4%）
- Carcinogen Classification： 对人类无致癌性迹象（未被IARC列出）。
- Drug Induced Liver Injury： 参考文献：DOI:10.1016/j.drudis.2019.09.022
- Effects During Pregnancy and Lactation： 尚未进行研究以确定咪康唑是否可能影响男性生育能力(使伴侣怀孕的能力)或增加高于背景风险的出生缺陷风险。一般来说，父亲或精子捐献者所接触的物质不太可能增加妊娠风险。更多信息，请参阅MotherToBaby事实表父方暴露在 https://mothertobaby.org/fact-sheets/paternal-exposures-pregnancy/。
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Research chemical CAS 22916-47-8 1ml
Yuanye Research chemical CAS 22916-47-8 1ml, complete specifications; suitable for production, research, laboratory testing and inspection; digital one-stop procurement platform for scientific materials.
