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Product introduction

OSI-930是一种新型有效的Flt1、激酶插入结构域受体（KDR）、CSF-1R、Lck、c-Raf和活化受体酪氨酸激酶Kit的抑制剂，IC50值分别为8、9、15、22、41和80 nM。在其存活高度依赖于Kit 信号的HMC-1细胞系中，OSI-930抑制细胞增殖，诱导细胞凋亡。反之，在正常培养条件下的COLO-205细胞系中，OSI-930不抑制细胞生长。 OSI-930可时间和浓度依赖地使P450 3A4失去活性。此外，OSI-930可减少P450 3A4的CO差光谱。 OSI-930是一种有效的Kit (c-Kit)， KDR和CSF-1R抑制剂，IC50分别为80 nM， 9 nM和15 nM，对Flt-1， c-Raf和Lck具有适度的抑制活性，对PDGFRα/β， Flt-3和Abl抑制活性较弱。

Specs ⸢ View details ⸥

Chinese name

OSI-930,Kit (c-Kit)， KDR和CSF-1R抑制剂, 集落刺激因子 1 受体抑制剂

English name

OSI-930

Chinese alias

English alias

AKOS026750567 | BDBM50356877 | SMR004701347 | HMS3295O11 | OSI 930 | NSC800811 | NSC-800811 | CELASTROL [MI] | CHEBI:91433 | BRD-K25340465-001-01-2 | 3-(quinolin-4-ylmethylamino)-N-(4-(trifluoromethoxy)phenyl)thiophene-2-carboxamide | OSI930 | OSI-930 | N

CAS number

728033-96-3

molecular formula

C22H16F3N3O2S

molecular weight

443.45 g/mol

Exact mass

PSA

91.500 Å²

Logp

6.2

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Research chemical CAS 728033-96-3 1ml

Name: Research chemical CAS 728033-96-3 1ml
Brand: 源叶
SKU: T94357-1ml

Yuanye Research chemical CAS 728033-96-3 1ml, complete specifications; suitable for production, research, laboratory testing and inspection; digital one-stop procurement platform for scientific materials.

item number：T94357-1ml

Product model：1ml

level： 1ml

Lead Time：30days

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Research chemical CAS 728033-96-3 1ml

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