PF-05198007 is a potent, orally active and selective arylsulfonamide Na v 1.7 inhibitor. PF-05198007 is a compound with a similar pharmacodynamic profile to PF-05089771 In Vitro PF-05198007 (30 nM) blocks on average 83.0 ± 2.7% of the total TTX-S current indicating that the major TTX-S conductance is carried through Na v 1.7 channels in small-diameter mouse DRG neurons (n = 35). MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo PF-05198007 (1 or 10 mg/kg, orally) reduces the capsaicin flare response in WT, but not Na v 1.7Na v 1.8Cre mice . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Adult Male C57Bl/6J Wild type (WT) and Na v 1.7Na v 1.8Cre mice . Dosage: 1 or 10 mg/kg. Administration: Orally once. Result: Reduced the flare response to capsaicin for the duration of the observation period (55 mins; Vehicle; 4930 ± 751 versus 1 and 10 mg/kg 1967 ± 472 and 2265 ± 382, respectively (n = 7), AUC, p Form:Solid IC50& Target:Nav1.7