微管运动蛋白 HSET 的变构抑制剂 Information CW069 CW069 is an allosteric, and selective inhibitor of microtubule motor protein HSET with IC50 of 75 μM, significant selectivity over KSP. Targets HSET 75 μM In vitro CW069 increases multipolar spindles in N1E-115 cells with supernumerary centrosomes without altering bipolar spindle morphology in normal human dermal fibroblast cells. CW069 inhibits growth in cancer N1E-115 cells with IC50 of 10 μM, but not in NHDF or primary human bone marrow cells. Cell Research(from reference) Cell lines：N1E-115 cells, NHDF and primary human bone marrow cells. Concentrations：~400 μM Incubation Time：72 hours