JAK2 JH2 Tracer (Tracer 5) is a fluorescent probe for JAK2 JH2 domain, with a K d of value 0.2 μM. In Vitro JAK2 JH2 Tracer shows a minimum tracer concentration that retains a satisfactory signal-to-noise ratio is found to be 1.5 pM. JAK2 JH2 Tracer shows a dissociation constants near 0.2 μM. JAK2 JH2 Tracer shows a high binding affinity with a K d value of 0.2 μM for JAK2 JH2 domain by saturation experiments. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo The possibility that mutations within the JAK2 JH2 domain may be associated with pathology, which is associated with a hyperactive kinase and a hematopoietic malignancy phenotype in flies. Specific mutation in the JAK2 JH2 domain is associated with several myeloproliferative diseases. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid