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Product introduction

AGN-195183 (IRX-5183) is a potent and selective agonist of RARα ( K d =3 nM) with improved binding selectivity relative to AGN 193836. AGN-195183 has no activity on RARβ/γ. In Vitro AGN-195183 (IRX-5183; Compound 4) inhibits the growth of breast cancer cell lines, and is inactive in an in vivo model of topical irritation.\nAGN-195183 and ATRA inhibit growth of the human breast cancer cell lines, T-47D and SK-BR-3. AGN-195183 does not cause the topical irritation induced by the RARa-selective retinoid, Am-580. AGN-195183 is currently in Phase I/IIA clinical trials in cancer patients. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:IC50 value: 3 nM (Kd),200 nM (EC80, RAR Trans)

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Chinese name

AGN-195183, 视黄酸受体α激动剂

English name

AGN-195183

Chinese alias

English alias

HY-16684 | 4-[(4-chloro-3-hydroxy-5,5,8,8-tetramethyl-6,7-dihydronaphthalene-2-carbonyl)amino]-2,6-difluorobenzoic acid | RC87L028HU | SCHEMBL5531052 | VTP-5183 | Q27288046 | AGN 195183 | BDBM50120065 | DB05653 | 4-[(4-Chloro-3-hydroxy-5,5,8,8-tetramethyl

CAS number

367273-07-2

molecular formula

C22H22ClF2NO4

molecular weight

437.86 g/mol

Exact mass

≥99%

PSA

86.600 Å²

Logp

6.4

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Research chemical CAS 367273-07-2 1ml

Name: Research chemical CAS 367273-07-2 1ml
Brand: 源叶
SKU: T98116-1ml

Yuanye Research chemical CAS 367273-07-2 1ml, complete specifications; suitable for production, research, laboratory testing and inspection; digital one-stop procurement platform for scientific materials.

item number：T98116-1ml

Product model：1ml

level： 1ml

Lead Time：30days

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Research chemical CAS 367273-07-2 1ml

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