储存在-20℃。存放在干燥的条件下。该产品最多可存储12个月。 ML141 (CID-2950007) 是 Rho 家族GTPase cdc42的一种有效的，选择性可逆非竞争性抑制剂，IC50为200 nM。对cdc42比对其他Rho家族中的GTPases(如Rac1, Rab2, Rab7)更有选择性。 ML141 与 p38 激活增加有关，并可能诱导p38依赖性凋亡/衰老。ML141还可保护神经母细胞瘤细胞免受二甲双胍(metformin)诱导的凋亡。ML141 (CID-2950007) 是一种高效、变构、选择性、可逆的 Cdc42 GTPase 非竞争性抑制剂。ML141 抑制 Cdc42 野生型和 Cdc42 Q61L 突变体的 EC50 值分别为 2.1 和 2.6 μM。ML141 对 GTPases Rho 家族的其他成员 (Rac1, Rab2, Rab7) 表现出低的微极性和选择性。ML141 在多个细胞系中没有显示细胞毒性。 Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. Application ML 141 has been used: to inhibit CDC42 GTPase in human immortalized gingival epithelial (HIGE) cells as inhibitors of Rho kinase to study the role of small Rho GTPases on localization of peripheral nuclei as actin regulator inhibitor, to determine which actin regulators and nucleators are involved in the assembly of F-actin cages around damaged mitochondria as a selective, non-competitive inhibitor of Cdc42 to treat CCD-1070Sk cells