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T0467 activates parkin mitochondrial translocation in a PINK1-dependent manner in vitro. T0467 do not induce mitochondrial accumulation of PINK1in dopaminergic neurons. T0467 is a potential compound for PINK1-Parkin signaling activation, and can be used for parkinson's disease and related disorders research. In Vitro T0467 (2.5-20 μM; 3 hours) stimulates the mitochondrial translocation of GFP-Parkinover 12 μM in HeLa/GFP-Parkin cells. When HeLa/GFP-Parkin cells are treated with 20 μM T0467 for 3 h, GTP-Parkin is translocated to the mitochondria in approximately 21% of cells. T0467 does not show obvious toxicity in Drosophila at concentrations Form:Solid

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Chinese name

T0467

English name

T0467

Chinese alias

English alias

CAS number

859518-94-8

molecular formula

C24H26F3N5

molecular weight

441.49 g/mol

Exact mass

≥99%

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Research chemical CAS 859518-94-8 1ml

Name: Research chemical CAS 859518-94-8 1ml
Brand: 源叶
SKU: T99496-1ml

Yuanye Research chemical CAS 859518-94-8 1ml, complete specifications; suitable for production, research, laboratory testing and inspection; digital one-stop procurement platform for scientific materials.

item number：T99496-1ml

Product model：1ml

level： 1ml

Lead Time：30days

sold 249 Items

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Research chemical CAS 859518-94-8 1ml

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