
- Treatment: 给予炭浆。(T273)
- Hazard summary: 已在人体中测试用于缓解妊娠期间的恶心和呕吐;长期摄入克量可导致共济失调和感觉神经病变;已在大鼠中显示出睾丸毒性;[REPROTOX] 刺激物;可能有累积不良影响;[Alfa Aesar MSDS] 见吡哆素盐酸盐。
- exposure pathway: 口服;肠外(肌肉注射)。B族维生素很容易从胃肠道吸收,除非在吸收不良综合征中。吡哆醇主要在空肠被吸收。
- Toxicity summary: 维生素B6是一组三种相关化合物的总称,包括吡哆醇(PN)、吡哆醛(PL)和吡哆胺(PM),以及它们的磷酸化衍生物,即吡哆醇5'-磷酸(PNP)、吡哆醛5'-磷酸(PLP)和吡哆胺5'-磷酸(PMP)。尽管从技术上讲所有这六种化合物都应被称为维生素B6,但维生素B6这一术语通常仅与其中一种吡哆醇互换使用。维生素B6主要以其生物活性辅酶形式吡哆醛5'-磷酸参与广泛的生化反应,包括氨基酸和糖原的代谢、核酸、血红蛋白、神经鞘磷脂和其他鞘脂的合成,以及神经递质血清素、多巴胺、去甲肾上腺素的合成...
- Regulatory information: 新西兰EPA化学品清单状态:吡哆醇:没有单独批准,但可在适当的团体标准下使用
- Toxicity Data: LD50:4克/公斤(口服,大鼠)
- Symptoms and Signs: 毒性作用包括惊厥、呼吸困难、活动过度、腹泻、共济失调和肌肉无力。
- Other safety information: 化学品评估:评估-不太可能需要进一步监管以管理环境风险的化学品
- Hazard categories and classifications: STOT SE 3 (94.2%)
- Carcinogen Classification: 对人类无致癌性迹象(未被IARC列出)。
- Drug Induced Liver Injury: 参考文献:DOI:10.1016/j.drudis.2019.09.022
- Effects During Pregnancy and Lactation: 一项随机、前瞻性但非盲法研究比较了卡麦角胺1mg(单次剂量或0.25mg每日两次,持续2天;n=45)与吡哆醇200mg每日三次,持续7天(n=43)在产后不愿哺乳女性中抑制泌乳的效果。治疗在分娩后约24小时开始。根据患者自我评估,卡麦角胺在抑制泌乳方面比吡哆醇更有效(78%比35%),并且在减轻乳房胀痛方面效果更好(89%比67%),第7天时卡麦角胺组乳汁渗漏频率低于吡哆醇组(7天后9%比42%,14天后11%比31%)。头痛和便秘是最常报告的不良反应,在卡麦角胺患者中发生频率更高(15%比2%)。
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Research chemical 50g
Research chemical 50g; supplied for laboratory research, analysis, inspection, and scientific procurement use; specifications: 50g.




