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Product introduction

U-73343 是U-73122 的无活性类似物，可作为阴性对照。U-73343 剂量依赖性的抑制酸分泌。U-73122 是有效的磷脂酶 C (phospholipase C) 和 5-脂氧合酶 (5-LO (5-lipoxygenase)) 抑制剂，对磷脂酶 C 的 IC50 值约为 1-2.1 µM。 Product description： U-73343, works as a protonophore, is an inactive analog of U-73122 and can be used as a negative control. U-73343 dose-dependently inhibits acid secretion irrespective of the stimulant. U-73122 is a phospholipase C (PLC) and 5-LO (5-lipoxygenase) inhibitor with an IC50 of 1-2.1 µM for PLC。 Application： U-73343 has been used for studying the role of phospholipase C (PLC) signaling in modulating epithelial Na+ channel (ENaC) function in gerbil Reissner′s membranes (RMs). U-73343 has also been used as a negative control for PLC inhibition in mechanically stimulated (MS) and its neighboring (NB) cells. U-73343 has been used in measuring the fluorescence of intracellular Ca2+.

Specs ⸢ View details ⸥

Chinese name

U-73343,U73122的的无效类似物

English name

U-73343

Chinese alias

1-[6-[(3-甲氧基-13-甲基-6,7,8,9,11,12,14,15,16,17-十氢环戊[[]菲基-17-基)氨基]己基]吡咯烷-2,5-dione

English alias

CAS number

142878-12-4

molecular formula

C29H42N2O3

molecular weight

466.7 g/mol

Exact mass

≥98%

PSA

58.600 Å²

Logp

3.600

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