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Product introduction

ULK-101是一种有效的、选择性的ULK1抑制剂，对ULK1和ULK2的IC50值分别为8.3 nM和30 nM。 Information ULK-101 ULK-101 is a potent and selective ULK1 inhibitor with IC50 values of 8.3 nM and 30 nM for ULK1 and ULK2, respectively. Targets ULK1 (Cell-free assay); ULK2 (Cell-free assay) 8.3 nM; 30 nM In vitro ULK-101 suppresses autophagy induction and autophagic flux in response to different stimuli. ULK-101 sensitizes KRAS mutant lung cancer cells to nutrient stress. Cell Research(from reference) Cell lines：U2OS cells Concentrations：5 μM Incubation Time：2.5 h

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Chinese name

ULK-101

English name

ULK-101

Chinese alias

English alias

(S)-N-(1-cyclopropyl-2,2,2-trifluoroethyl)-4-(6-(4-fluorophenyl)pyrazolo[1,5-a]pyrimidin-3-yl)thiophene-2-carboxamide

CAS number

2443816-45-1

molecular formula

C22H16F4N4OS

molecular weight

460.45 g/mol

Exact mass

≥98%

PSA

87.500 Å²

Logp

4.363

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