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Product details

名称

USP7-IN-1

分子类型

未知

英文名称

USP7-IN-1

货号

U648748-5mg

包装规格

5mg

浓度

≥98%

储存温度

-20°C储存

运输条件

超低温冰袋运输

产品介绍

USP7-IN-1 is a selective and reversible inhibitor of ubiquitin-specific protease 7 (USP7) , with an IC 50 of 77 μM, and can be used for the research of cancer . In Vitro USP7-IN-1 (Example 2) is a selective and reversible inhibitor of USP7, with an IC 50 of 77 μM, and shows no inhibition of USP8, USP5, Uch-L1, Uch-L3 or caspase 3. USP7-IN-1 inhibits the proliferation of HCT116 cells, with a GI 50 of 67 μM. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:IC50: 77 μM (USP7)

生化机理

USP7-IN-1 是泛素特异性蛋白酶 7（USP7）的一种选择性可逆抑制剂，IC 50 为 77 μM，可用于癌症研究。

CAS号

1381291-36-6

分子式

C23H24ClN3O3

分子量

425.91 g/mol

PubChem编号

71278663

Isomeric SMILES

C1CN(CCC1(CN2C=NC3=C(C2=O)C=CC(=C3)Cl)O)C(=O)CCC4=CC=CC=C4

IIUPAC Name

7-chloro-3-[[4-hydroxy-1-(3-phenylpropanoyl)piperidin-4-yl]methyl]quinazolin-4-one

INCHI

1S/C23H24ClN3O3/c24-18-7-8-19-20(14-18)25-16-27(22(19)29)15-23(30)10-12-26(13-11-23)21(28)9-6-17-4-2-1-3-5-17/h1-5,7-8,14,16,30H,6,9-13,15H2

InChi Key

CITWIBXKKHFDFM-UHFFFAOYSA-N

Smiles

C1CN(CCC1(CN2C=NC3=C(C2=O)C=CC(=C3)Cl)O)C(=O)CCC4=CC=CC=C4

PubChem CID

71278663

溶解性

DMSO : 100 mg/mL (234.79 mM; Need ultrasonic)

氢键供体数Hydrogen Bond Donor Count

氢键受体数Hydrogen Bond Acceptor Count

可旋转键计数Rotatable Bond Count

精确质量Exact Mass

425.151 Da

单同位素质量Monoisotopic Mass

425.151 Da

拓扑极表面积Topological Polar Surface Area

73.200 Å²

重原子数Heavy Atom Count

形式电荷Formal Charge

复杂度Complexity

656.000

同位素原子数Isotope Atom Count

共价键合单元计数Covalently-Bonded Unit Count

XLogP3

2.600

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

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