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Product details

名称

UAMC-3203 hydrochloride

分子类型

小分子

别名

UAMC-3203盐酸盐

英文名称

UAMC-3203 hydrochloride

货号

U649006-5mg

包装规格

5mg

浓度

≥99%

储存温度

2-8°C储存,避光,干燥

运输条件

冰袋运输

产品介绍

UAMC-3203 hydrochloride is a potent and selective Ferroptosis inhibitor with an IC 50 of 12 nM In Vivo No toxicity is observed in mice after repeated injections of UAMC-3203 (20 µmol/kg; injected intraperitoneally; daily, over a period of 4 weeks) . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Wild type mice derived from a Gpx4 fl/fl breeding Dosage: 20 µmol/kg Administration: Injected intraperitoneally; daily, over a period of 4 weeks Result: No toxicity was observed. Form:Solid IC50& Target:IC50: 12 nM (Ferroptosis)

生化机理

UAMC-3203 盐酸盐是一种强效的选择性铁突变抑制剂，其 IC 50 为 12 nM。

CAS号

2271358-65-5

分子式

C25H38ClN5O2S

分子量

508.1 g/mol

PubChem编号

137701964

Isomeric SMILES

C1CCC(CC1)NC2=C(C=C(C=C2)S(=O)(=O)NCCN3CCNCC3)NCC4=CC=CC=C4.Cl

IIUPAC Name

3-(benzylamino)-4-(cyclohexylamino)-N-(2-piperazin-1-ylethyl)benzenesulfonamide;hydrochloride

INCHI

1S/C25H37N5O2S.ClH/c31-33(32,28-15-18-30-16-13-26-14-17-30)23-11-12-24(29-22-9-5-2-6-10-22)25(19-23)27-20-21-7-3-1-4-8-21;/h1,3-4,7-8,11-12,19,22,26-29H,2,5-6,9-10,13-18,20H2;1H

InChi Key

WBZHHIZXEXJBSM-UHFFFAOYSA-N

Smiles

C1CCC(CC1)NC2=C(C=C(C=C2)S(=O)(=O)NCCN3CCNCC3)NCC4=CC=CC=C4.Cl

PubChem CID

137701964

溶解性

DMSO : 50 mg/mL (98.40 mM; Need ultrasonic)

氢键供体数Hydrogen Bond Donor Count

氢键受体数Hydrogen Bond Acceptor Count

可旋转键计数Rotatable Bond Count

精确质量Exact Mass

507.243 Da

单同位素质量Monoisotopic Mass

507.243 Da

拓扑极表面积Topological Polar Surface Area

93.900 Å²

重原子数Heavy Atom Count

形式电荷Formal Charge

复杂度Complexity

652

同位素原子数Isotope Atom Count

共价键合单元计数Covalently-Bonded Unit Count

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

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