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Product details

名称

UK-371804

分子类型

小分子

别名

英国-371804

英文名称

UK-371804

货号

U650696-5mg

包装规格

5mg

浓度

≥98%

储存温度

-20°C储存

运输条件

超低温冰袋运输

产品介绍

UK-371804 is a urokinase-type plasminogen activator ( uPA ) inhibitor with a K i of 10 nM. In Vitro UK-371804 is able to inhibit exogenous uPA in human chronic wound fluid (IC 50 =0.89 μM). UK-371804 has its excellent enzyme potency (K i =10 nM) and selectivity profile (4000-fold versus tPA and 2700-fold versus plasmin). MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo In a porcine acute excisional wound model, following topical delivery, UK-371804 is able to penetrate into pig wounds and inhibit exogenous uPA activity with no adverse effect on wound healing parameters. Concentrations of UK-371804 in the dermis are 41.8 μM . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:Ki: 10 nM (uPA)

生化机理

UK-371804 是一种尿激酶型纤溶酶原激活剂（uPA）抑制剂，K i 为 10 nM。

CAS号

256477-09-5

分子式

C14H16ClN5O4S

分子量

385.83 g/mol

PubChem编号

9952109

Isomeric SMILES

CC(C)(C(=O)O)NS(=O)(=O)C1=CC2=C(C=C1)C(=CN=C2N=C(N)N)Cl

IIUPAC Name

2-[[4-chloro-1-(diaminomethylideneamino)isoquinolin-7-yl]sulfonylamino]-2-methylpropanoic acid

INCHI

1S/C14H16ClN5O4S/c1-14(2,12(21)22)20-25(23,24)7-3-4-8-9(5-7)11(19-13(16)17)18-6-10(8)15/h3-6,20H,1-2H3,(H,21,22)(H4,16,17,18,19)

InChi Key

XSDAXWRCPTYNOD-UHFFFAOYSA-N

Smiles

CC(C)(C(=O)O)NS(=O)(=O)C1=CC2=C(C=C1)C(=CN=C2N=C(N)N)Cl

PubChem CID

9952109

MeSH Entry Terms

2-(((4-chloro-1-guanidino-7-isoquinolinyl)sulfonyl)amino)isobutyric acid;UK 371,804;UK 371804;UK-371,804;UK-371804;UK371,804;UK371804

溶解性

DMSO : 8.33 mg/mL (21.59 mM; Need ultrasonic)

氢键供体数Hydrogen Bond Donor Count

氢键受体数Hydrogen Bond Acceptor Count

可旋转键计数Rotatable Bond Count

精确质量Exact Mass

385.061 Da

单同位素质量Monoisotopic Mass

385.061 Da

拓扑极表面积Topological Polar Surface Area

169.000 Å²

重原子数Heavy Atom Count

形式电荷Formal Charge

复杂度Complexity

644.000

同位素原子数Isotope Atom Count

共价键合单元计数Covalently-Bonded Unit Count

XLogP3

0.700

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

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