UKI-1

小分子

BDBM23891 | MS-30724 | WX-UK1 | AKOS030526723 | ethyl 4-[(2S)-3-(3-carbamimidoylphenyl)-2-{[2,4,6-tris(propan-2-yl)benzene]sulfonamido}propanoyl]piperazine-1-carboxylate | A911340 | UNII-00LOF6890B | 3-amidinophenylalanine deriv., 35 | 1-Piperazinecarboxy

UKI-1

U651172-5mg

5mg

≥96%

-20°C储存

超低温冰袋运输

UKI-1 (WX-UK1) is a potent urokinase-type plasminogen activator (uPA) inhibitor with a K i of 0.41 μM. UKI-1 is also a low molecular weight serine protease inhibitor. UKI-1 is a potent antimetastatic agent and inhibits the invasive capacity of carcinoma cells In Vitro UKI-1 (WX-UK1; 0.1-1.0 μg/mL) treatment shows a decrease of tumor cell invasion by up to 50% is achieved in both models with the SCCHN line FaDu and the cervical carcinoma line HeLa. UKI-1 (WX-UK1) interferes with the plasminogen activation system at 2 levels: it inhibits plasmin formation directly and via inhibition of uPA. In vitro invasion models with highly invasive fibrosarcoma and breast cancer cells showed that UKI-1 effectively inhibits migration of the cells through fibrin matrices. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo UKI-1 (WX-UK1) treatment has antimetastatic activities that significantly reduces the number of metastatic lesions and tumor growth in metastasizing rat pancreatic and mammary adenocarcinoma tumor models . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:Ki: 0.41 μM (Urokinase-type plasminogen activator (uPA)),Serine protease

UKI-1（WX-UK1）是一种强效的尿激酶型纤溶酶原激活剂（uPA）抑制剂，其 K i 为 0.41 μM。UKI-1 还是一种低分子量丝氨酸蛋白酶抑制剂。UKI-1 是一种有效的抗转移剂，可抑制癌细胞的侵袭能力。

220355-63-5

C32H47N5O5S

613.81 g/mol

9895193

CCOC(=O)N1CCN(CC1)C(=O)[C@H](CC2=CC(=CC=C2)C(=N)N)NS(=O)(=O)C3=C(C=C(C=C3C(C)C)C(C)C)C(C)C

ethyl 4-[(2S)-3-(3-carbamimidoylphenyl)-2-[[2,4,6-tri(propan-2-yl)phenyl]sulfonylamino]propanoyl]piperazine-1-carboxylate

1S/C32H47N5O5S/c1-8-42-32(39)37-14-12-36(13-15-37)31(38)28(17-23-10-9-11-24(16-23)30(33)34)35-43(40,41)29-26(21(4)5)18-25(20(2)3)19-27(29)22(6)7/h9-11,16,18-22,28,35H,8,12-15,17H2,1-7H3,(H3,33,34)/t28-/m0/s1

ISJSHQTWOHGCMM-NDEPHWFRSA-N

CCOC(=O)N1CCN(CC1)C(=O)C(CC2=CC(=CC=C2)C(=N)N)NS(=O)(=O)C3=C(C=C(C=C3C(C)C)C(C)C)C(C)C

9895193

220355-63-5

N-alpha-(2,4,6-triisopropyl-phenylsulfonyl)-3-amidino-(L)-phenyl-alanine-4-ethoxycarbonyl-piperazide hydrochloride;WX-UK1

DMSO : 100 mg/mL (162.92 mM; Need ultrasonic)

3

7

12

613.33 Da

613.33 Da

154.000 Ų

43

0

1030

0

1

4.8