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Product details

名称

UK-371804

分子类型

小分子

别名

英国-371804

英文名称

UK-371804

货号

U656378-1ml

包装规格

1ml

浓度

10mM in DMSO

储存温度

-80℃储存

运输条件

超低温冰袋运输

产品介绍

UK-371804 is a urokinase-type plasminogen activator ( uPA ) inhibitor with a K i of 10 nM. In Vitro UK-371804 is able to inhibit exogenous uPA in human chronic wound fluid (IC 50 =0.89 μM). UK-371804 has its excellent enzyme potency (K i =10 nM) and selectivity profile (4000-fold versus tPA and 2700-fold versus plasmin). MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo In a porcine acute excisional wound model, following topical delivery, UK-371804 is able to penetrate into pig wounds and inhibit exogenous uPA activity with no adverse effect on wound healing parameters. Concentrations of UK-371804 in the dermis are 41.8 μM . MCE has not independently confirmed the accuracy of these methods. They are for reference only. IC50& Target:Ki: 10 nM (uPA)

生化机理

UK-371804 是一种尿激酶型纤溶酶原激活剂（uPA）抑制剂，K i 为 10 nM。

CAS号

256477-09-5(DMSO)

分子式

C14H16ClN5O4S

分子量

385.83 g/mol

Smiles

CC(C)(C(=O)O)NS(=O)(=O)C1=CC2=C(C=C1)C(=CN=C2N=C(N)N)Cl

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

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「No technical documents」

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