Information UK-371804 HCl UK-371804 is a potent and selective urokinase-type plasmogen activator (uPA) inhibitor with excellent enzyme potency (Ki=10 nM) and selectivity profile (4000-fold versus tPA and 2700-fold versus plasmin). Targets uPA (Cell-free assay) 10 nM(Ki) In vitro UK-3718046 is able to inhibit exogenous uPA in human chronic wound fluid (IC50=0.89 µM). In vivo in a porcine acute excisional wound model, following topical delivery, UK-3718046 is able to penetrate into pig wounds and inhibit exogenous uPA activity with no adverse effect on wound healing parameters.