应用 Buchwald环钯配合物带有 EPhos 配体的预催化剂，用于 Pd 催化伯胺和芳基卤化物之间的 C-N 交叉偶联，形成 2-芳基氨基恶唑。报告了 NaOPh 的催化系统 (CDS001581).。它是第四代 (G4)Buchwald预催化剂，除了联苯骨架上的氨基被甲基化外，与第三代 (G3) 预催化剂相似。这种修饰有助于防止使用第三代预催化剂的局限性。它是空气，水分和热稳定，并显示出良好的溶解性，在常见的有机溶剂。BrettPhos Pd G4 在交叉偶联反应中非常有用。它具有催化剂用量少、反应时间短、能有效地形成活性物种、能精确控制配体钯比等优点。['Buchwald Description Buchwald palladacycle precatalyst with EPhos ligand for Pd-catalyzed C–N cross-coupling between primary amines and aryl halides to form 2-arylaminooxazoles. Catalyst system was reported with NaOPh (CDS001581).It is a fourth generation (G4)Buchwaldprecatalyst that is similar to the third generation (G3) precatalysts except that the amino group on the biphenyl backbone is methylated. This modification helps to prevent the limitations of using the third generation precatalysts. It is air, moisture and thermally-stable and shows good solubility in common organic solvents. BrettPhos Pd G4 is highly useful in cross-coupling reactions. Some of its excellent features include lower catalyst loadings, shorter reaction time, and efficient formation of the active catalytic species and accurate control of ligand: palladium ratio.