拉莫三嗪-13C3 是拉莫三嗪的同位素标记形式。拉莫三嗪可作为突触前神经元电压门控钠通道的抑制剂。研究表明，拉莫三嗪以剂量依赖性方式阻断了培养的小鼠脊髓中神经元的持续重复放电。这些研究表明，拉莫三嗪可有效抑制谷氨酸和天冬氨酸的释放，但对乙酰胆碱和GABA的释放没有影响。拉莫三嗪通过肝葡萄糖醛酸化作用被肝微粒体灭活。据信拉莫三嗪以类似于苯妥英钠和卡马西平的方式调节快速电压依赖性钠电流。此外，拉莫三嗪对钠电流引起的去极化电势表现出较小的频率依赖性抑制。拉莫三嗪-13C3由于其同位素标记而在研究中可能是有益的， Lamotrigine-13C3 is an isotopically labeled form of Lamotrigine . Lamotrigine functions as an inhibitor of voltage gated sodium channels of presynaptic neurons. Studies indicate that Lamotrigine blocked sustained repetitive firing of neurons in a dose dependent manner in cultured mouse spinal cords. These studies indicate that Lamotrigine is effective at suppressing the release of glutamate and aspartate, but have no effect on acetylcholine and GABA release. Lamotrigine is inactivated by liver microsomes, via hepatic glucuronidation. It is believed that Lamotrigine modulates the fast voltage-dependent sodium currents in a manner similar to phenytoin and carbamazepine . Furthermore, Lamotrigine displays a small frequency dependent inhibition of depolarized potentials that result from sodium currents. Lamotrigine-13C3 can be beneficial in research due to its isotopic label, which makes identification of the molecule easier|in situ|.