Vigabatrin hydrochloride

小分子

盐酸氨己烯酸

Vigabatrin hydrochloride

V647228-50mg

50mg

≥99%

2-8°C储存

冰袋运输

Vigabatrin hydrochloride (γ-Vinyl-GABA hydrochloride), a inhibitory neurotransmitter GABA vinyl-derivative, is an orally active and irreversible GABA transaminase inhibitor. Vigabatrin hydrochloride is an antiepileptic agent, which acts by increasing GABA levels in the brain by inhibiting the catabolism of GABA by GABA transaminase . In Vitro A significant increase in seizure threshold is observed following systemic (i.p.) administration of high (600 or 1200 mg/kg) doses of Vigabatrin. Bilateral microinjection of Vigabatrin (10 μg) into either the anterior or posterior substantia nigra pars reticulata (SNr) also increased seizure threshold, but less markedly than systemic treatment. Focal delivery into the subthalamic nucleus (STN) increased seizure threshold more markedly than either intranigral or systemic administration of Vigabatrin. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo Vigabatrin inhibits the uptake of taurine in Caco-2 and MDCK cells to 34% and 53%, respectively, at a concentration of 30 mM. In Caco-2 cells the uptake of Vigabatrin under neutral pH conditions is concentration-dependent and saturable with a Km-value of 27 mM. Vigabatrin is able to inhibit the uptake of taurine in intestinal and renal cell culture models. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid

盐酸维加溴铵（γ-乙烯基-GABA 盐酸盐）是一种抑制性神经递质 GABA 乙烯基衍生物，是一种口服活性不可逆 GABA 转氨酶抑制剂。盐酸维加溴铵是一种抗癫痫药，通过增加 GABA

1391054-02-6

C6H12ClNO2

165.62 g/mol

71666447

C=CC(CCC(=O)O)N.Cl

4-aminohex-5-enoic acid;hydrochloride

1S/C6H11NO2.ClH/c1-2-5(7)3-4-6(8)9;/h2,5H,1,3-4,7H2,(H,8,9);1H

FBNKOYLPAMUOHS-UHFFFAOYSA-N

C=CC(CCC(=O)O)N.Cl

71666447

H2O : 33.33 mg/mL (201.24 mM; Need ultrasonic) DMSO : 27.5 mg/mL (166.04 mM; Need ultrasonic and warming)

3

3

4

165.056 Da

165.056 Da

63.300 Ų

10

0

112.000

0

2