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Product details

名称

Vicagrel

分子类型

小分子

别名

维卡格雷

英文别名

英文名称

Vicagrel

货号

V647442-5mg

包装规格

5mg

浓度

≥98%

储存温度

-20°C储存

运输条件

超低温冰袋运输

产品介绍

Vicagrel is a potent, safe and orally active antiplatelet agent, which works by irreversibly inhibiting P2Y12 receptor. Vicagrel can be used for the research of blood clots in coronary artery disease, peripheral vascular disease, and cerebrovascular disease. In Vitro Vicagrel (compound 9a) (20 μM, 30 min) activates production of the active metabolite from in vitro rat liver microsomal. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo Vicagrel (compound 9a) (oral, 3 mg/kg) has inhibitory effect on ADP-induced platelet aggregation in rats . Vicagrel (oral, 1.14 mg/mL, 0-24 h) has giood preliminary pharmacokinetic with high bioavailability and low clinically effective dose . Vicagrel (oral, 5 g/kg, single, for 14 days) has low dose-related toxicity in mouse . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Male Wistar rats (200−250 g) Dosage: 3 mg/kg Administration: oral Result: Inhibitied platelet aggregation by ADP-induced in rats. Animal Model: SD male rats Dosage: 1.14 mg/mL Administration: oral, 0-24 h Result: Could be readily converted into clopidogrel thiolactone and had high bioavailability. Animal Model: Mice Dosage: 5 g/kg Administration: oral, single, for 14 days Result: Had very low acute toxicity. Form:Solid

生化机理

Vicagrel 是一种强效、安全、口服活性抗血小板药物，通过不可逆地抑制 P2Y12 受体发挥作用。Vicagrel 可用于研究冠状动脉疾病、外周血管疾病和脑血管疾病中的血栓。

CAS号

1314081-53-2

分子式

C18H18ClNO4S

分子量

379.86 g/mol

PubChem编号

53378151

Isomeric SMILES

CC(=O)OC1=CC2=C(S1)CCN(C2)[C@@H](C3=CC=CC=C3Cl)C(=O)OC

IIUPAC Name

methyl (2S)-2-(2-acetyloxy-6,7-dihydro-4H-thieno[3,2-c]pyridin-5-yl)-2-(2-chlorophenyl)acetate

INCHI

1S/C18H18ClNO4S/c1-11(21)24-16-9-12-10-20(8-7-15(12)25-16)17(18(22)23-2)13-5-3-4-6-14(13)19/h3-6,9,17H,7-8,10H2,1-2H3/t17-/m0/s1

InChi Key

GNHHCBSBCDGWND-KRWDZBQOSA-N

Smiles

CC(=O)OC1=CC2=C(S1)CCN(C2)C(C3=CC=CC=C3Cl)C(=O)OC

PubChem CID

53378151

关联CAS

1314081-53-2

MeSH Entry Terms

methyl 2-(2-acetoxy-6,7-dihydrothieno(3,2-c)pyridin-5(4H)-yl)-2-(2-chlorophenyl)acetate;vicagrel

溶解性

DMSO : 250 mg/mL (658.14 mM; Need ultrasonic)

氢键供体数Hydrogen Bond Donor Count

氢键受体数Hydrogen Bond Acceptor Count

可旋转键计数Rotatable Bond Count

精确质量Exact Mass

379.065 Da

单同位素质量Monoisotopic Mass

379.065 Da

拓扑极表面积Topological Polar Surface Area

84.100 Å²

重原子数Heavy Atom Count

形式电荷Formal Charge

复杂度Complexity

505

同位素原子数Isotope Atom Count

共价键合单元计数Covalently-Bonded Unit Count

XLogP3

3.8

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

user reviews

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