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Product introduction

ALZ-801 is a potent and orally available small-molecule β-amyloid (Aβ) anti-oligomer and aggregation inhibitor, valine-conjugated proagent of Tramiprosate with substantially improved PK properties and gastrointestinal tolerability compared with the parent compound ALZ-801 is an advanced and markedly improved candidate for the treatment of alzheimer’s disease . In Vivo ALZ-801 (oral administration; 172?mg/kg; single dose) exhibits mean AUCt values of 58,758 and? 5841 ng/ml.h in plasma and brain, respectively. The ALZ-801: Tramiprosate ratio in plasma and brain is 1.8 and 3.1, respectively in male CD-1 mice . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:β-amyloid

Specs ⸢ View details ⸥

Chinese name

Valiltramiprosate, β 淀粉样蛋白 A4 蛋白稳定剂

English name

Valiltramiprosate

Chinese alias

丙咪嗪

English alias

ALZ-801 | 3-[[(2S)-2-amino-3-methylbutanoyl]amino]propane-1-sulfonic acid | VALILTRAMIPROSATE [INN] | NRM-8499 | HY-117259 | BLU8499 | 3-(valylamino)-1-propanesulfonic acid | 1-Propanesulfonic acid, 3-(((2S)-2-amino-3-methyl-1-oxobutyl)amino)- | 3-((2S)-2

CAS number

1034190-08-3

molecular formula

C8H18N2O4S

molecular weight

238.30 g/mol

Exact mass

≥98%

PSA

118.000 Å²

Logp

-3

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