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Product details

名称

(S)-Verapamil hydrochloride

别名

(S)-盐酸维拉帕米

英文别名

英文名称

(S)-Verapamil hydrochloride

货号

V651432-5mg

包装规格

5mg

浓度

≥99%

储存温度

2-8°C储存

运输条件

冰袋运输

产品介绍

(S)-Verapamil hydrochloride (S(-)-Verapamil hydrochloride) inhibits leukotriene C4 (LTC4) and calcein transport by MRP1. (S)-Verapamil hydrochloride leads to the death of potentially resistant tumor cells In Vitro (S)-Verapamil hydrochloride (S(-)-Verapamil hydrochloride) not the (R)-Verapamil hydrochloride potently induces the death of MRP1-transfected BHK-21 cells. (S)-Verapamil hydrochloride is good active form and has the low bioavailability. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:LTC 4

生化机理

(S)-盐酸维拉帕米（S(-)-Verapamil hydrochloride）可抑制白三烯 C4（LTC4）和钙黄绿素通过 MRP1 转运。(S)-盐酸维拉帕米可导致具有潜在抗药性的肿瘤细胞死亡。

CAS号

36622-28-3

分子式

C27H39ClN2O4

分子量

491.1 g/mol

EC号

253-132-8

PubChem编号

12249889

Isomeric SMILES

CC(C)[C@](CCCN(C)CCC1=CC(=C(C=C1)OC)OC)(C#N)C2=CC(=C(C=C2)OC)OC.Cl

IIUPAC Name

(2S)-2-(3,4-dimethoxyphenyl)-5-[2-(3,4-dimethoxyphenyl)ethyl-methylamino]-2-propan-2-ylpentanenitrile;hydrochloride

INCHI

1S/C27H38N2O4.ClH/c1-20(2)27(19-28,22-10-12-24(31-5)26(18-22)33-7)14-8-15-29(3)16-13-21-9-11-23(30-4)25(17-21)32-6;/h9-12,17-18,20H,8,13-16H2,1-7H3;1H/t27-;/m0./s1

InChi Key

DOQPXTMNIUCOSY-YCBFMBTMSA-N

Smiles

CC(C)C(CCCN(C)CCC1=CC(=C(C=C1)OC)OC)(C#N)C2=CC(=C(C=C2)OC)OC.Cl

PubChem CID

12249889

关联CAS

36622-28-3

溶解性

DMSO : 200 mg/mL (407.28 mM; Need ultrasonic) H2O : 100 mg/mL (203.64 mM; Need ultrasonic)

氢键供体数Hydrogen Bond Donor Count

氢键受体数Hydrogen Bond Acceptor Count

可旋转键计数Rotatable Bond Count

精确质量Exact Mass

490.26 Da

单同位素质量Monoisotopic Mass

490.26 Da

拓扑极表面积Topological Polar Surface Area

64.000 Å²

重原子数Heavy Atom Count

形式电荷Formal Charge

复杂度Complexity

606

同位素原子数Isotope Atom Count

共价键合单元计数Covalently-Bonded Unit Count

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

user reviews

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