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Product details

名称

VAS 3947

别名

增值税 3947

英文名称

VAS 3947

货号

V651645-5mg

包装规格

5mg

浓度

≥99%

储存温度

-20°C储存

运输条件

超低温冰袋运输

产品介绍

VAS 3947, a specific NADPH oxidase (NOX) inhibitor, exerts a potent antiplatelet effect. VAS3947 induces apoptosis independently of anti-NOX activity, via UPR activation, mainly due to aggregation and misfolding of proteins. In Vitro VAS3947 consistently inhibits NADPH oxidase activity in low micromolar concentrations, and interferes neither with ROS detection nor with XOD or eNOS activities. VAS3947 (30 µM) does not interfere with xanthine/XOD-derived L012 signals, suggesting this compound is free of antioxidant or scavenging effects relevant to ROS detection. In CaCo-2 cell homogenates, VAS3947 completely blocks NADPH-dependent ROS production with an IC 50 of 12 µM. VAS3947 triggers cell proliferation arrest and death independently of anti-NOX activity. The IC 50 values of the different cell lines ranges from 2.6 ± 0.6 µM for the most sensitive cell line MV-4-11 to 4.9 µM for THP-1, the least sensitive. VAS3947 decreases ROS levels. VAS3947 triggers endoplasmic reticulum (ER) stress and consequent unfolding protein response (UPR). VAS3947 attenuates platelet activation and thrombus formation via a NOX-independent pathway downstream of PKC 3] . MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo NADPH 氧化酶抑制剂 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid

生化机理

VAS 3947 是一种特异性 NADPH 氧化酶（NOX）抑制剂，具有强效抗血小板作用。VAS3947 可通过 UPR 激活（主要是由于蛋白质的聚集和错误折叠）诱导细胞凋亡，而与抗 NOX 活性无关。

CAS号

869853-70-3

分子式

C14H10N6OS

分子量

310.33 g/mol

PubChem编号

7471335

Isomeric SMILES

C1=CC=C(C=C1)CN2C3=C(C(=NC=N3)SC4=NC=CO4)N=N2

IIUPAC Name

2-(3-benzyltriazolo[4,5-d]pyrimidin-7-yl)sulfanyl-1,3-oxazole

INCHI

1S/C14H10N6OS/c1-2-4-10(5-3-1)8-20-12-11(18-19-20)13(17-9-16-12)22-14-15-6-7-21-14/h1-7,9H,8H2

InChi Key

JVZDLDFNSCFLPM-UHFFFAOYSA-N

Smiles

C1=CC=C(C=C1)CN2C3=C(C(=NC=N3)SC4=NC=CO4)N=N2

PubChem CID

7471335

MeSH Entry Terms

3-benzyl-7-(2-oxazolyl)thio-1,2,3-triazolo(4,5-d)pyrimidine;VAS 3947;VAS-3947;VAS3947

溶解性

DMSO : 100 mg/mL (322.24 mM; Need ultrasonic)

氢键供体数Hydrogen Bond Donor Count

氢键受体数Hydrogen Bond Acceptor Count

可旋转键计数Rotatable Bond Count

精确质量Exact Mass

310.064 Da

单同位素质量Monoisotopic Mass

310.064 Da

拓扑极表面积Topological Polar Surface Area

108.000 Å²

重原子数Heavy Atom Count

形式电荷Formal Charge

复杂度Complexity

369

同位素原子数Isotope Atom Count

共价键合单元计数Covalently-Bonded Unit Count

XLogP3

2.5

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

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