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Product details

名称

Vornorexant

分子类型

未知

别名

沃诺雷生

英文名称

Vornorexant

货号

V651734-5mg

包装规格

5mg

浓度

≥99%

储存温度

-20°C储存

运输条件

超低温冰袋运输

产品介绍

Vornorexant (ORN-0829; TS-142) is a potent dual OX1R and OX2R antagonist with IC 50 values of 1.05 nM and 1.27 nM, respectively. Vornorexant exhibits potent sleep-promoting effects? in vivo and can be used for insomnia research research In Vivo Vornorexant (oral administration; 1-10 mg/kg) exhibits potent sleep-promoting effects at a po. dose of 1 mg/kg in a rat polysomnogram study. It results in a dose-dependent increase in the percentage of total sleep . Vornorexant exhibits optimal PK properties with a rapid T max and short half-lives in rats and dogs. The T 1/2 is 0.238 hours and 1.16 hours, respectively in rat and dog . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Rat Dosage: 1, 3, 10 mg/kg Administration: Oral administration to rats prior to turning the light off (start of the active phase); 1-10 mg/kg Result: Possessed promising sleep-inducing and sleep-promoting effects. Form:Solid IC50& Target:OX 2 Receptor

生化机理

Vornorexant（ORN-0829；TS-142）是一种强效的OX1R和OX2R双重拮抗剂，IC50值分别为1.05 nM和1.27 nM。Vornorexant 在体内具有强效的促进睡眠作用，可用于失眠研究。

CAS号

1517965-94-4

分子式

C23H22FN7O2

分子量

447.46 g/mol

PubChem编号

137419776

Isomeric SMILES

CC1=CC(=C(C=C1)N2N=CC=N2)C(=O)N3CCCO[C@H]3CN4C=CC(=N4)C5=NC=C(C=C5)F

Smiles

CC1=CC(=C(C=C1)N2N=CC=N2)C(=O)N3CCCO[C@H]3CN4C=CC(=N4)C5=NC=C(C=C5)F

PubChem CID

137419776

溶解性

DMSO : ≥ 100 mg/mL (223.48 mM)

氢键供体数Hydrogen Bond Donor Count

氢键受体数Hydrogen Bond Acceptor Count

可旋转键计数Rotatable Bond Count

精确质量Exact Mass

447.182 Da

单同位素质量Monoisotopic Mass

447.182 Da

拓扑极表面积Topological Polar Surface Area

91.000 Å²

重原子数Heavy Atom Count

形式电荷Formal Charge

复杂度Complexity

667

同位素原子数Isotope Atom Count

共价键合单元计数Covalently-Bonded Unit Count

XLogP3

2.5

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

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