Valecobulin

伐可布林

Valecobulin

V654602-1ml

1ml

10mM in DMSO

-80℃储存

超低温冰袋运输

Valecobulin (CKD516) is a valine proagent of (S516) and a vascular disrupting agent (VDA). Valecobulin is a potent β-tubulin polymerization inhibitor with marked antitumor activity against murine and human solid tumors In Vivo Valecobulin (5 mg/kg; intraperitoneal injection; administered on days 2, 6, 10, and 14; male BALB/C nu/nu mice) treatment shows markedly antitumor efficacy in various human tumor xenograft models . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Male BALB/C nu/nu mice (5-6 weeks of age) with HCT-116 or HCT-15 cells Dosage: 5 mg/kg Administration: Intraperitoneal injection; administered on days 2, 6, 10, and 14 Result: Had shown marked antitumor efficacy in various human tumor xenograft models. IC50& Target:β-tubulin polymerization

Valecobulin（CKD516）是（S516）的一种缬氨酸原药，也是一种血管破坏剂（VDA）。Valecobulin 是一种强效的 β-微管蛋白聚合抑制剂，对小鼠和人类实体瘤具有显著的抗肿瘤活性。

1188371-47-2(DMSO)

C26H28N6O5S

536.60 g/mol

CC(C)C(C(=O)NC1=NC(=CS1)C2=CC(=C(C=C2)C(=O)C3=CC(=C(C(=C3)OC)OC)OC)N4C=NC=N4)N