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名称

Vornorexant

别名

沃诺雷生

英文名称

Vornorexant

货号

V656803-1ml

包装规格

1ml

浓度

10mM in DMSO

储存温度

-80℃储存

运输条件

超低温冰袋运输

产品介绍

Vornorexant (ORN-0829; TS-142) is a potent dual OX1R and OX2R antagonist with IC 50 values of 1.05 nM and 1.27 nM, respectively. Vornorexant exhibits potent sleep-promoting effects? in vivo and can be used for insomnia research research In Vivo Vornorexant (oral administration; 1-10 mg/kg) exhibits potent sleep-promoting effects at a po. dose of 1 mg/kg in a rat polysomnogram study. It results in a dose-dependent increase in the percentage of total sleep . Vornorexant exhibits optimal PK properties with a rapid T max and short half-lives in rats and dogs. The T 1/2 is 0.238 hours and 1.16 hours, respectively in rat and dog . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Rat Dosage: 1, 3, 10 mg/kg Administration: Oral administration to rats prior to turning the light off (start of the active phase); 1-10 mg/kg Result: Possessed promising sleep-inducing and sleep-promoting effects. IC50& Target:OX 2 Receptor

生化机理

Vornorexant（ORN-0829；TS-142）是一种强效的OX1R和OX2R双重拮抗剂，IC50值分别为1.05 nM和1.27 nM。Vornorexant 在体内具有强效的促进睡眠作用，可用于失眠研究。

CAS号

1517965-94-4(DMSO)

分子式

C23H22FN7O2

分子量

447.46 g/mol

Smiles

O=C(N1[C@@H](OCCC1)CN2N=C(C3=CC=C(C=N3)F)C=C2)C4=C(N5N=CC=N5)C=CC(C)=C4

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

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