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Product details

名称

VcMMAE-d8

英文名称

VcMMAE-d8

货号

V767817-1mg

包装规格

1mg

储存温度

-20°C储存

运输条件

超低温冰袋运输

敏感性

对湿度敏感

产品介绍

VcMMAE-d8 是 VcMMAE（HY-15575）的同位素。VcMMAE-d8 是抗体偶联活性分子的一部分 (drug-linker conjugate for ADC)，具有抗癌活性，它由 MMAE (一种 tubulin 抑制剂) 和 valine-citrulline (vc) 连接而成。在溶剂中：-80°C，6个月-20°C，1个月（密封储存，远离水分）体外研究： ADC 由一种抗体组成，ADC 细胞毒素通过 ADC 接头连接到该抗体上。 VcMMAE-d8 is an isotope of VcMMAE (HY-15575). VcMMAE-d8 is a part of the drug linker conjugate for ADC, which has anti-cancer activity. It is composed of MMAE (a tubulin inhibitor) and valine citrulline (VC). In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) In vitro studies: ADC is composed of an antibody, and ADC cytotoxin is connected to the antibody through an ADC adapter.

生化机理

VcMMAE-d8 is an isotope of VcMMAE. VcMMAE-d8 is a agent-linker conjugate for ADC with potent antitumor activity by using the anti-mitotic agent, monomethyl auristatin E (MMAE, a tubulin inhibitor), linked via the lysosomally cleavable dipeptide, valine-citrulline (vc).

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