JNJ-9350 is an inhibitor of spermine oxidase ( SMOX ) with an IC 50 value of 0.01 μM. JNJ-9350 also inhibits polyamine oxidase ( PAO ) with an IC 50 value of 0.79 μM. JNJ-9350 can be used for the research of cancer In Vitro JNJ-9350 (0-100 μM) shows inhibitory effect to SMOX, PAO and LSD1 with IC 50 values of 10 nM, 790 nM and ＞60 μM, respectively. JNJ-9350 (1.1-70 µM) binds with SMOX with a K i value of 9.9 nM. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo 1.19 Pharmacokinetic Properties of JNJ-9350 in Mice . Mice PO 10 mg/kg Clearance (mL/min/kg) (Total/Unbound) 73/5217 Volume of distribution (L/kg) 1.7 Half-life (min) 16 PPB (Mouse) 98.6% Oral F% 34% MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:IC50: 10 nM (SMOX), 790 nM (PAO), ＞60 μM (LSD1)